CJC-1295 + Ipamorelin
Limited human evidence
What is it?
CJC-1295 is a synthetic analogue of growth-hormone-releasing hormone, while ipamorelin activates the ghrelin receptor. Together, they are intended to stimulate the body's pulsatile release of growth hormone and increase downstream IGF-1 signalling.
Indication / Area studied
Growth-hormone secretion, body composition, recovery and sleep-related outcomes. Human evidence for the combination is limited, and it is not an established treatment for general anti-ageing or body-composition management.
AOD-9604
No established indication
What is it?
AOD-9604 is a modified fragment of human growth hormone corresponding to part of its C-terminal region. It was developed to investigate whether some of growth hormone's effects on fat metabolism could be separated from its growth-promoting activity.
Indication / Area studied
Obesity, fat metabolism and body-fat reduction. Clinical development for obesity did not demonstrate sufficiently convincing efficacy, and AOD-9604 has no established therapeutic indication.
Tesamorelin
Approved · specific indication
What is it?
Tesamorelin is a synthetic analogue of growth-hormone-releasing hormone. It stimulates the pituitary gland to release endogenous growth hormone, which subsequently increases IGF-1.
Indication / Area studied
Reduction of excess abdominal fat in adults with HIV-associated lipodystrophy. It is approved for this specific indication in the United States and is not approved there as a general weight-loss treatment.
PEG-MGF
Predominantly preclinical
What is it?
PEG-MGF is a pegylated synthetic form related to mechano growth factor, an IGF-1 splice variant associated with the local cellular response to mechanical stress and muscle injury.
Indication / Area studied
Muscle repair, regeneration and adaptation following mechanical loading. Research is predominantly preclinical, with no established therapeutic indication or adequate human safety evidence.
IGF-1 LR3
Experimental compound
What is it?
IGF-1 LR3 is a modified, longer-acting analogue of insulin-like growth factor 1. It is designed to remain biologically active for longer and interact less strongly with IGF-binding proteins than natural IGF-1.
Indication / Area studied
Cell growth, muscle development, tissue repair and metabolic signalling. IGF-1 LR3 is an experimental research compound and should not be confused with approved pharmaceutical forms of recombinant human IGF-1.
GHRP-2 / GHRP-6
Limited human evidence
What is it?
GHRP-2 and GHRP-6 are synthetic growth-hormone secretagogues that activate the ghrelin receptor, stimulating the release of endogenous growth hormone. GHRP-6 is also associated with a more pronounced effect on appetite.
Indication / Area studied
Growth-hormone release, growth-hormone deficiency research, appetite regulation and body-composition outcomes. Neither peptide has an established indication for routine anti-ageing, recovery or physique management.